A new weight loss study has found that drug brands Zepbound and Mounjaro led to more weight loss compared to Ozempic and Wegovy. The active ingredient in Zepbound and Mounjaro is tirzepatide, while the active ingredient in Ozempic and Wegovy is semaglutide. This new study published by JAMA Internal Medicine found patients taking the highest Zepbound dose lost about 21% of their body weight during a 72-week period. Meanwhile, patients on the highest dose of Wegovy lost around 15% of their body weight during a 68-week period.